An
RNA virus is a
virus that has
RNA (ribonucleic acid) as its
genetic material.
This
nucleic acid is usually single-stranded RNA (ssRNA) but may be double-stranded RNA (dsRNA).
The
ICTV classifies RNA viruses as those that belong to
Group III,
Group IV or
Group V of the
Baltimore classification system of classifying viruses, and does not consider viruses with DNA intermediates as RNA viruses. Notable human diseases caused by RNA viruses include
SARS,
influenza and
hepatitis C.
Another term for RNA viruses that explicitly excludes
retroviruses is
ribovirus.
Characteristics
Single-stranded RNA viruses and RNA Sense
RNA viruses can be further classified according to the sense or polarity of their RNA into
negative-sense and
positive-sense, or ambisense RNA viruses. Positive-sense viral RNA is similar to mRNA and thus can be immediately
translated by the host cell. Negative-sense viral RNA is complementary to mRNA and thus must be converted to positive-sense RNA by an
RNA polymerase
before translation. As such, purified RNA of a positive-sense virus can
directly cause infection though it may be less infectious than the
whole virus particle. Purified RNA of a negative-sense virus is not
infectious by itself as it needs to be
transcribed into positive-sense RNA, however each
virion can be transcribed to several positive-sense RNAs.
Ambisense RNA viruses resemble negative-sense RNA viruses, except they also translate genes from the positive strand.
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